Ganeshappa Anjana, Krambeck Amy, Grignon David J, Lingeman James E
Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
J Endourol. 2009 Aug;23(8):1277-9. doi: 10.1089/end.2009.0126.
Keratinizing desquamative squamous metaplasia (KDSM), also known as leukoplakia or cholesteatoma, of the genitourinary tract is a rare condition that is difficult to differentiate from a malignant process without surgical intervention. We present a case of KDSM of the upper urinary tract that was managed via percutaneous endoscopic approach. Although KDSM is a benign lesion, there are rare reports of it occurring concurrently with squamous-cell carcinoma; however, no direct causal relationship has been identified. This case demonstrates the ease with which KDSM can be removed by peeling it away from the underlying parenchyma; however, surgical intervention may not be necessary in the asymptomatic patient after evaluation has ruled out malignancy. Regardless of how KDSM is managed, follow-up is important because these lesions are known to recur.
泌尿生殖道的角化脱屑性鳞状化生（KDSM），也称为白斑或胆脂瘤，是一种罕见疾病，若无手术干预则难以与恶性病变相鉴别。我们报告一例经皮内镜治疗的上尿路KDSM病例。尽管KDSM是良性病变，但有罕见报道称其与鳞状细胞癌同时发生；然而，尚未确定直接因果关系。本病例表明，通过将KDSM从其下方的实质组织上剥离，很容易将其切除；然而，在评估排除恶性病变后，无症状患者可能无需手术干预。无论KDSM如何治疗，随访都很重要，因为已知这些病变会复发。
