Song Yan, Wang Lv-Hua, He Jie, Wang Jin-Wan
Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, P. R. China.
Ai Zheng. 2009 Mar;28(3):303-7.
The treatment and prognosis of primary esophageal small cell carcinoma (PESC), an uncommon esophageal malignant tumor, have seldom been reported. This study was to analyze the clinical characteristics, treatment and prognosis of PESC.
Clinical data of 151 patients treated in Cancer Hospital, Chinese Academy of Medical Sciences, from 1982 to 2007 were reviewed. The median age of the patients was 59 years. According to VALSG criteria, 138 patients had limited disease (LD), 13 had extensive disease (ED). Patients received surgery, chemotherapy and/or radiotherapy. The survival rate was calculated by the Kaplan-Meier method and the log-rank test using SPSS 13.0 software.
The 6, 12, 24, 36 and 60-month survival rates of these patients were 86.6%, 56.7%, 24.8%,17.4% and 12.0% respectively. The clinical stage and vessel involvement were independent prognostic factors of PESC. The median survival time was longer in LD patients(12.3 months) than in those underwent local treatment alone (surgery or radiotherapy).
PESC is a malignant tumor with early metastasis and poor prognosis. Combined therapy based on chemotherapy may improve the short term survival of PESC patients.
原发性食管小细胞癌（PESC）是一种罕见的食管恶性肿瘤，其治疗方法及预后鲜有报道。本研究旨在分析PESC的临床特征、治疗方法及预后情况。
回顾性分析1982年至2007年在中国医学科学院肿瘤医院接受治疗的151例患者的临床资料。患者的中位年龄为59岁。根据VALSG标准，138例患者为局限性疾病（LD），13例为广泛性疾病（ED）。患者接受了手术、化疗和/或放疗。采用Kaplan-Meier法计算生存率，并使用SPSS 13.0软件进行对数秩检验。
这些患者的6个月、12个月、24个月、36个月和60个月生存率分别为86.6%、56.7%、24.8%、17.4%和12.0%。临床分期和血管侵犯是PESC的独立预后因素。LD患者的中位生存时间（12.3个月）长于单纯接受局部治疗（手术或放疗）的患者。
PESC是一种早期转移且预后较差的恶性肿瘤。基于化疗的综合治疗可能会提高PESC患者的短期生存率。
