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本文引用的文献

1
Internal dynamics of a living cell nucleus investigated by dynamic light scattering.通过动态光散射研究活细胞核的内部动力学。
Eur Phys J E Soft Matter. 2008 Aug;26(4):435-48. doi: 10.1140/epje/i2007-10346-5.
2
Measuring structural dynamics of chromosomes in living cells by fluorescence microscopy.通过荧光显微镜测量活细胞中染色体的结构动力学。
Methods. 2007 Feb;41(2):158-67. doi: 10.1016/j.ymeth.2006.07.035.
3
Gene expression within a dynamic nuclear landscape.动态核环境中的基因表达。
EMBO J. 2006 Aug 9;25(15):3469-79. doi: 10.1038/sj.emboj.7601226. Epub 2006 Jul 13.
4
Chromatin structure exhibits spatio-temporal heterogeneity within the cell nucleus.染色质结构在细胞核内表现出时空异质性。
Biophys J. 2006 Sep 15;91(6):2297-303. doi: 10.1529/biophysj.105.079525. Epub 2006 Jun 30.
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The road much traveled: trafficking in the cell nucleus.常走的路：细胞核中的运输
Curr Opin Cell Biol. 2006 Jun;18(3):284-90. doi: 10.1016/j.ceb.2006.03.002. Epub 2006 Apr 18.
6
Dissecting the contribution of diffusion and interactions to the mobility of nuclear proteins.剖析扩散和相互作用对核蛋白流动性的贡献。
Biophys J. 2006 Mar 15;90(6):1878-94. doi: 10.1529/biophysj.105.071241. Epub 2005 Dec 30.
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Subnuclear organelles: new insights into form and function.亚核细胞器：关于形态与功能的新见解
Trends Cell Biol. 2006 Jan;16(1):19-26. doi: 10.1016/j.tcb.2005.11.005. Epub 2005 Dec 1.
8
Chromatin dynamics in interphase cells revealed by tracking in a two-photon excitation microscope.通过双光子激发显微镜追踪揭示的间期细胞中的染色质动力学。
Biophys J. 2005 Dec;89(6):4275-85. doi: 10.1529/biophysj.105.066670. Epub 2005 Sep 8.
9
Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-gamma and TRAIL.使用细胞生长抑制剂与γ干扰素和肿瘤坏死因子相关凋亡诱导配体联合用药对神经母细胞瘤细胞凋亡的协同诱导作用
Int J Oncol. 2004 Dec;25(6):1849-57.
10
Visualization of early chromosome condensation: a hierarchical folding, axial glue model of chromosome structure.早期染色体凝缩的可视化：染色体结构的分级折叠、轴向黏合模型
J Cell Biol. 2004 Sep 13;166(6):775-85. doi: 10.1083/jcb.200406049. Epub 2004 Sep 7.

间期活细胞核的全球内部动力学演变。

Evolution of the global internal dynamics of a living cell nucleus during interphase.

作者信息

Suissa M, Place C, Goillot E, Freyssingeas E

机构信息

Université de Lyon, Laboratoire de Physique, CNRS UMR 5672, Ecole Normale Supérieure de Lyon, 69364 Lyon, France.

出版信息

Biophys J. 2009 Jul 22;97(2):453-61. doi: 10.1016/j.bpj.2009.04.046.

DOI:10.1016/j.bpj.2009.04.046
PMID:19619459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2711314/
Abstract

Progress in cellular biology based on fluorescent microscopy techniques, shows that the spatial organization of the nucleus is dynamic. This dynamic is very complex and involves a multitude of phenomena that occur on very different time and size scales. Using an original light scattering experimental device, we investigated the global internal dynamics of the nucleus of a living cell according to the phases of the cell cycle. This dynamic presents two different and independent kinds of relaxation that are well separated in time and specific to the phase of the cell cycle.

摘要

基于荧光显微镜技术的细胞生物学进展表明，细胞核的空间组织是动态的。这种动态非常复杂，涉及在非常不同的时间和大小尺度上发生的多种现象。我们使用一种原始的光散射实验装置，根据细胞周期的阶段研究了活细胞核的整体内部动态。这种动态呈现出两种不同且独立的弛豫类型，它们在时间上有很好的区分，并且特定于细胞周期的阶段。