López Soriano F, Rivas López F A, Crespo Toral J, López Robles J, de la Rubia M A, Azurmendi Rodríguez J I, Mendoza Cerezo A
Servicio de Anestesiología y Reanimación. Servicio de Farmacia, Hospital del Noroeste de Murcia, Caravaca. Murcia.
Rev Esp Anestesiol Reanim. 1991 May-Jun;38(3):170-2.
By means of the present study, we compare the variations in the cardiovascular response to the orotracheal intubation while using midazolam or etomidate during the anesthetic induction. For this purpose, we studied 2 groups of 10 patients each one which were premedicated with fentanyl and atropine, and succinylcholine as muscle relaxant. We took the data at a basal state, 10 minutes after premedication and 0, 1, 2, 3, 4, 5 and 10 minutes after the intubation handling. As hemodynamic data we registered heart rate, systolic and diastolic blood pressure and the rate product (PRP). In both groups, the peak response occurred two minutes after intubation in all the studied parameters. Systolic and diastolic blood pressure as well as PRP were significantly lower with midazolam. We conclude that midazolam and etomidate do not prevent the cardiovascular response to the intubation handling, although midazolam smooths pressure response.
通过本研究，我们比较了在麻醉诱导期间使用咪达唑仑或依托咪酯时，经口气管插管引起的心血管反应变化。为此，我们研究了两组患者，每组10例，均预先使用芬太尼和阿托品进行预处理，并使用琥珀酰胆碱作为肌肉松弛剂。我们在基础状态、预处理后10分钟以及插管操作后0、1、2、3、4、5和10分钟采集数据。作为血流动力学数据，我们记录了心率、收缩压和舒张压以及心率与收缩压乘积（PRP）。在两组中，所有研究参数的峰值反应均出现在插管后两分钟。使用咪达唑仑时，收缩压和舒张压以及PRP显著较低。我们得出结论，咪达唑仑和依托咪酯不能预防插管操作引起的心血管反应，尽管咪达唑仑可使血压反应更平稳。
