用抗白细胞介素-5治疗一例儿童嗜酸性粒细胞增多综合征

Treatment of a case of pediatric hypereosinophilic syndrome with anti-interleukin-5.

作者信息

Mehr Sam, Rego Sylvan, Kakakios Alyson, Kilham Henry, Kemp Andrew

机构信息

Department of Allergy & Immunology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

出版信息

J Pediatr. 2009 Aug;155(2):289-91. doi: 10.1016/j.jpeds.2009.01.058.

DOI:10.1016/j.jpeds.2009.01.058

PMID:19619754

Abstract

We report the use of anti-interleukin-5 (mepolizumab) during an 18-month period in a pediatric hypereosinophilic syndrome. Infusions every 3 months allowed better control of hypereosinophilic syndrome flares and maintained blood eosinopenia with significantly less steroid use compared with all other therapies (prednisolone alone, interferon alpha, or imatinib mesylate).

摘要

我们报告了在18个月期间，抗白细胞介素-5（美泊利单抗）在儿童高嗜酸性粒细胞综合征中的应用情况。与所有其他疗法（单独使用泼尼松龙、干扰素α或甲磺酸伊马替尼）相比，每3个月进行一次输注能更好地控制高嗜酸性粒细胞综合征发作，并维持血液嗜酸性粒细胞减少，且显著减少了类固醇的使用。