Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea.
Eur J Radiol. 2010 Jul;75(1):e22-8. doi: 10.1016/j.ejrad.2009.06.015. Epub 2009 Jul 19.
To retrospectively evaluate previous imaging findings of breast cancers that occurred in women whose combined screening using both mammography and ultrasonography was negative.
A search of the institutional database identified 65 patients with breast cancers who had comparable previous negative screening mammography and ultrasonography (BI-RADS category 1 or 2) within 2 years. We classified each case as true or false negative. The previous imaging findings and the final outcome were analyzed.
Among 65 cases, 42 (65%) were true negatives, 23 (35%) were false negatives. The abnormalities of false negatives were underestimated in 16 (70%) and unrecognized in 7 (30%). The findings were calcifications (n=8) or a mass (n=6) on mammography, a mass (n=5) or a non-mass (n=3) on ultrasonography and a density on mammography correlated with non-mass on ultrasonography (n=1). Ductal carcinoma in situ among false and true negatives accounted for 5 (22%) and 7 (17%), respectively. Symptomatic cancers among false and true negatives were 6 (26%) and 13 (31%), respectively.
Breast cancers that rarely occurred in combined screening negatives are often retrospectively seen as minimal abnormalities on previous imaging studies.
回顾分析在乳腺钼靶和超声联合筛查阴性的女性中发生的乳腺癌的既往影像学表现。
通过对机构数据库的检索，共发现 65 例在 2 年内均有类似的阴性筛查钼靶和超声（BI-RADS 类别 1 或 2）的乳腺癌患者。我们将每个病例分为真阴性和假阴性。分析了既往的影像学表现和最终的结果。
在 65 例患者中，42 例（65%）为真阴性，23 例（35%）为假阴性。假阴性的异常在 16 例（70%）中被低估，在 7 例（30%）中未被识别。假阴性的表现为钼靶上的钙化（n=8）或肿块（n=6）、超声上的肿块（n=5）或非肿块（n=3）和与超声上的非肿块相对应的钼靶密度（n=1）。假阴性和真阴性中的导管原位癌分别占 5 例（22%）和 7 例（17%）。假阴性和真阴性中症状性癌症分别为 6 例（26%）和 13 例（31%）。
在乳腺钼靶和超声联合筛查阴性的患者中，很少发生乳腺癌，这些患者的既往影像学研究通常显示为轻微异常。
