Busan Pierpaolo, Battaglini Piero Paolo, Borelli Massimo, Evaristo Pasquale, Monti Fabrizio, Pelamatti Giovanna
BRAIN Center of Neuroscience, Department of Life Sciences, University of Trieste, Trieste, Italy.
Clin Neuropharmacol. 2009 Jul-Aug;32(4):183-8. doi: 10.1097/WNF.0b013e31819817eb.
Paroxetine has been reported to be useful for management of stuttering symptoms, but only a few reports have examined its effects. We have investigated the efficacy of paroxetine in a randomized, placebo-controlled study.
Five stuttering subjects received paroxetine at 20 mg once daily at night for 12 weeks, and 5 received placebo. The percentages of stuttered words and stuttering-associated movements during speech were measured at baseline and after 6 and 12 weeks of treatment. Moreover, left primary motor cortex excitability was measured using transcranial magnetic stimulation. Specifically, resting and active motor thresholds and the cortical silent period (CSP) were obtained at the same periods in both groups.
Paroxetine did not affect the percentage of stuttered words between groups. Stuttering-associated movements, however, during speech in facial muscular districts were significantly reduced in subjects treated with paroxetine. Finally, paroxetine administration shortened the CSP with no effect on motor thresholds.
Paroxetine may be useful in qualitative management of stuttering symptoms and may act on the stuttering brain by diminution of intracortical inhibition, as revealed by the shortening of the CSP after paroxetine administration.
据报道，帕罗西汀有助于治疗口吃症状，但仅有少数报告对其效果进行了研究。我们开展了一项随机、安慰剂对照研究，以调查帕罗西汀的疗效。
5名口吃受试者每晚服用20毫克帕罗西汀，每日1次，持续12周，另外5名受试者服用安慰剂。在基线以及治疗6周和12周后，测量言语过程中口吃单词的百分比以及与口吃相关的动作。此外，使用经颅磁刺激测量左侧初级运动皮层兴奋性。具体而言，在两组的相同时间段内获取静息和主动运动阈值以及皮层静息期（CSP）。
帕罗西汀对两组之间口吃单词的百分比没有影响。然而，在接受帕罗西汀治疗的受试者中，面部肌肉区域言语过程中与口吃相关的动作显著减少。最后，服用帕罗西汀缩短了CSP，但对运动阈值没有影响。
帕罗西汀可能有助于对口吃症状进行定性管理，并且可能通过减少皮层内抑制作用于口吃大脑，这在服用帕罗西汀后CSP缩短中得到体现。
