6p21.33 处的基因变异与滤泡性淋巴瘤易感性相关。
Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.
作者信息
Skibola Christine F, Bracci Paige M, Halperin Eran, Conde Lucia, Craig David W, Agana Luz, Iyadurai Kelly, Becker Nikolaus, Brooks-Wilson Angela, Curry John D, Spinelli John J, Holly Elizabeth A, Riby Jacques, Zhang Luoping, Nieters Alexandra, Smith Martyn T, Brown Kevin M
机构信息
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA.
出版信息
Nat Genet. 2009 Aug;41(8):873-5. doi: 10.1038/ng.419. Epub 2009 Jul 20.
Abstract
We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).
摘要
我们使用Illumina HumanHap550 BeadChips对非霍奇金淋巴瘤进行了全基因组关联研究，以确定在滤泡性、弥漫性大B细胞和慢性淋巴细胞白血病/小淋巴细胞淋巴瘤中的亚型特异性关联。我们发现，6p21.33上的rs6457327与滤泡性淋巴瘤（FL；189例病例，592例对照）的易感性相关，并在另外456例FL病例和2785例对照中得到验证（合并等位基因P = 4.7 x 10(-11)）。最强关联区域与位于银屑病易感区域1（PSORS1）附近的C6orf15（STG）重叠。
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