Skibola Christine F, Bracci Paige M, Halperin Eran, Conde Lucia, Craig David W, Agana Luz, Iyadurai Kelly, Becker Nikolaus, Brooks-Wilson Angela, Curry John D, Spinelli John J, Holly Elizabeth A, Riby Jacques, Zhang Luoping, Nieters Alexandra, Smith Martyn T, Brown Kevin M
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA.
Nat Genet. 2009 Aug;41(8):873-5. doi: 10.1038/ng.419. Epub 2009 Jul 20.
We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).
我们使用Illumina HumanHap550 BeadChips对非霍奇金淋巴瘤进行了全基因组关联研究，以确定在滤泡性、弥漫性大B细胞和慢性淋巴细胞白血病/小淋巴细胞淋巴瘤中的亚型特异性关联。我们发现，6p21.33上的rs6457327与滤泡性淋巴瘤（FL；189例病例，592例对照）的易感性相关，并在另外456例FL病例和2785例对照中得到验证（合并等位基因P = 4.7 x 10(-11)）。最强关联区域与位于银屑病易感区域1（PSORS1）附近的C6orf15（STG）重叠。
