College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305-764, South Korea.
J Drug Target. 2010 Jan;18(1):15-20. doi: 10.3109/10611860903115274.
Despite the advantages of drug delivery through skin, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept known as microneedle was introduced and could be used to pierce effectively to deliver drugs using micron-sized needles in a minimally invasive and painless manner. In this study, the polymer microneedle-roller was fabricated so that it can be applied into the permeation of L-ascorbic acid. Moreover, a recent publication suggested the possibility of ascorbic acid 2-phosphate as a hair restorer; hence, this study was carried out to check the effect of L-ascorbic acid itself on the hair growing rate in rats according to the presence of various application frequencies of the polymer microneedle-roller. When the polymer microneedle-roller was applied nine times with four directions into rat's shaved skin, the permeation of L-ascorbic acid increased by 10.54-fold compared to that of the absence of the polymer microneedle-roller. The histological examination revealed that the skin pretreated with various application frequencies of the polymer microneedle-roller had more transport pathways. The faster hair growing phenomenon was observed in the presence of polymer microneedle-roller compared to the absence of the polymer microneedle-roller.
尽管通过皮肤给药具有诸多优势，但由于大多数化合物无法以治疗上有用的速度穿透皮肤，因此只有一小部分药物可通过经皮给药。最近，一种新的概念，即微针，被引入并可用于以微创和无痛的方式使用微米大小的针有效地刺穿并输送药物。在这项研究中，制造了聚合物微针滚轮，以便可以将其应用于 L-抗坏血酸的渗透。此外，最近的一篇出版物提出了 2-磷酸抗坏血酸作为头发修复剂的可能性；因此，进行了这项研究以根据聚合物微针滚轮的各种应用频率的存在检查 L-抗坏血酸本身对大鼠毛发生长速度的影响。当聚合物微针滚轮以四个方向将 9 次应用于大鼠剃毛的皮肤时，与不存在聚合物微针滚轮相比，L-抗坏血酸的渗透增加了 10.54 倍。组织学检查显示，用聚合物微针滚轮进行各种应用频率预处理的皮肤具有更多的运输途径。与不存在聚合物微针滚轮相比，聚合物微针滚轮的存在观察到更快的毛发生长现象。
