Marti A, Santos J L, Gratacos M, Moreno-Aliaga M J, Maiz A, Martinez J A, Estivill X
Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, 31080 Pamplona, Navarra, Spain.
Nutr Neurosci. 2009 Aug;12(4):183-8. doi: 10.1179/147683009X423355.
Human and animal studies provide evidence for a relevant role of the leptin receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy homeostasis.
To assess the association between human LEPR and BDNF genetic variants with adult obesity.
Case-control study in Pamplona (Navarra, Spain) with adult obese subjects (n = 159) and normal weight controls (n = 154). Four common polymorphisms of the LEPR gene (Lys109Arg, Gln223Arg, Ser343Ser, Lys656Asn) and 17 variants of the BDNF gene, including the Val66Met variant, were genotyped.
No significant case-control differences were found in allele/genotype frequencies after adjusting for relevant co-variates. Haplotype analysis did not detect any significant association between LEPR or BDNF variants and obesity. No associations were found between LEPR variants and serum leptin levels.
Our results do not support a major role of LEPR or BDNF common polymorphisms in multifactorial adult obesity.
人类和动物研究为瘦素受体（LEPR）和脑源性神经营养因子（BDNF）基因在能量平衡中的相关作用提供了证据。
评估人类LEPR和BDNF基因变异与成人肥胖之间的关联。
在西班牙纳瓦拉省潘普洛纳市进行病例对照研究，纳入成年肥胖受试者（n = 159）和正常体重对照者（n = 154）。对LEPR基因的四种常见多态性（Lys109Arg、Gln223Arg、Ser343Ser、Lys656Asn）以及BDNF基因的17种变异（包括Val66Met变异）进行基因分型。
在对相关协变量进行校正后，等位基因/基因型频率在病例组和对照组之间未发现显著差异。单倍型分析未检测到LEPR或BDNF变异与肥胖之间存在任何显著关联。未发现LEPR变异与血清瘦素水平之间存在关联。
我们的结果不支持LEPR或BDNF常见多态性在多因素成人肥胖中起主要作用。
