Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
J Neuropsychiatry Clin Neurosci. 2009 Spring;21(2):114-25. doi: 10.1176/jnp.2009.21.2.114.
This systematic review aims to investigate neurobiological changes related to cognitive-behavioral therapy (CBT) in anxiety disorders detected through neuroimaging techniques and to identify predictors of response to treatment. Cognitive-behavioral therapy modified the neural circuits involved in the regulation of negative emotions and fear extinction in judged treatment responders. The only study on predictors of response to treatment was regarding obsessive-compulsive disorder and showed higher pretreatment regional metabolic activity in the left orbitofrontal cortex associated with a better response to behavioral therapy. Despite methodological limitations, neuroimaging studies revealed that CBT was able to change dysfunctions of the nervous system.
本系统综述旨在通过神经影像学技术研究与焦虑障碍相关的认知行为疗法（CBT）的神经生物学变化，并确定治疗反应的预测因素。认知行为疗法改变了调节负面情绪和恐惧消退的神经回路，在判断为治疗反应者中观察到了这种改变。唯一一项关于治疗反应预测因素的研究是关于强迫症的，研究显示，左眶额皮质的预处理区域代谢活性较高与对行为治疗的反应更好相关。尽管存在方法学限制，但神经影像学研究表明，CBT 能够改变神经系统的功能障碍。
