T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke.

作者信息

Donswijk M L, Jones P S, Guadagno J V, Carpenter T A, Moustafa R R, Fryer T D, Aigbirhio F I, Warburton E A, Baron J C

机构信息

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

出版信息

Cerebrovasc Dis. 2009;28(3):306-13. doi: 10.1159/000229017. Epub 2009 Jul 21.

BACKGROUND

Mapping high oxygen extraction fraction (OEF) in acute stroke is of considerable interest to depict the at-risk tissue. Being sensitive to deoxyhemoglobin, T2*-weighted MRI has been suggested as a potential marker of high OEF.

METHODS

We compared T2*-weighted images from pre-contrast arrival perfusion scans against quantitative positron emission tomography in 5 patients studied 7-21 h after onset of carotid territory stroke. OEF and T2* signal were obtained in the voxels with significantly high OEF.

RESULTS

All patients showed increased OEF. No significant relationship between OEF and T2*-weighted signal was found either within or between subjects.

CONCLUSION

We found no indication that T2*-weighted MRI in the way implemented in this investigation was sensitive to high OEF in acute stroke.