Ekstrøm Claus Thorn
Statistics, Department Of Natural Sciences, Faculty of LIFE Sciences, University of Copenhagen, Frederiksberg, Denmark.
Hum Hered. 2009;68(4):243-51. doi: 10.1159/000228922. Epub 2009 Jul 22.
Heritability measures the familial aggregation of a disease or trait and a non-zero heritability suggests that a genetic component may be present. Reliable heritability estimates are necessary in the planning phase of a linkage or genetic association study but often these estimates are obtained from other studies where the composition of pedigrees may be different from the study that is prepared. The impact of pedigree structure on precision and accuracy of heritability estimates is examined for data and models both with and without dominance effects. Analytical and simulation results find that for purely additive genetic effects all but the simplest pedigree structures provide the same information about the heritability of a quantitative trait. In the presence of dominance effects there is a substantial difference in the precision obtained by different pedigree structures.
遗传力衡量一种疾病或性状的家族聚集性，非零遗传力表明可能存在遗传成分。在连锁或基因关联研究的规划阶段，可靠的遗传力估计是必要的，但这些估计往往来自其他研究，而这些研究中的家系组成可能与准备开展的研究不同。针对有无显性效应的数据和模型，研究了家系结构对遗传力估计精度和准确性的影响。分析和模拟结果表明，对于纯加性遗传效应，除了最简单的家系结构外，所有家系结构提供的关于数量性状遗传力的信息相同。在存在显性效应的情况下，不同家系结构所获得的精度存在显著差异。
