Taoka Kazuki, Nannya Yasuhito, Yamamoto Go, Sakatani Takashi, Ota Satoshi, Fukayama Masashi, Takahashi Tsuyoshi, Kurokawa Mineo
Am J Hematol. 2009 Sep;84(9):600-3. doi: 10.1002/ajh.21479.
Epstein-Barr virus (EBV) associated lymphoproliferative disease (LPD) comprises a wide spectrum of clinical and pathological features [1]. This variety is most systematically categorized in post-transplant lymphoproliferative disorders (PTLD) [2], in which subtypes are ordered according to disease progression from reactive polyclonal proliferation to large cell lymphoma. However, whether this categorization is applicable to LPDs other than PTLD is not well explored. Here, we present a nontransplant case of EBV-LPD that initially presented as a polyclonal self-limiting proliferation and later transited to large cell lymphoma. This transition was associated with the progression of lung cancer and its therapy. Our case demonstrates that stepwise progression of LPD is a feature that can be observed in non-PTLD cases of EBV-LPD.
爱泼斯坦-巴尔病毒（EBV）相关淋巴增殖性疾病（LPD）具有广泛的临床和病理特征[1]。这种多样性在移植后淋巴增殖性疾病（PTLD）中分类最为系统[2]，其中亚型根据疾病从反应性多克隆增殖到弥漫大B细胞淋巴瘤的进展情况进行排序。然而，这种分类是否适用于PTLD以外的LPD尚未得到充分探讨。在此，我们报告一例非移植性EBV-LPD病例，该病例最初表现为多克隆自限性增殖，随后转变为弥漫大B细胞淋巴瘤。这种转变与肺癌进展及其治疗有关。我们的病例表明，LPD的逐步进展是EBV-LPD非PTLD病例中可观察到的一个特征。
