Nasser Selim M
Department of Pathology, Clemenceau Medical Center, Beirut, Lebanon.
J Med Liban. 2009 Apr-Jun;57(2):83-8.
Gene expression profiling has been increasingly used to determine new cancer markers. This technology holds major promises for improving the management of patients with breast cancer in which traditional clinicopathologic parameters do not account for all the heterogeneity of this disease and its distinct prognostic groups. Gene expression profiling has resulted in new classification of breast cancer and new assays are being developed and commercialized as prognostic and predictive tests. However, the use of these tests in a clinical setting presents many issues. The accuracy of this new technology is often overestimated and its limitations should be addressed. Although early results are promising, further validation and well designed clinical trials are required before incorporating these tests in routine clinical practice.
基因表达谱分析已越来越多地用于确定新的癌症标志物。这项技术有望极大地改善乳腺癌患者的治疗，因为在乳腺癌中，传统的临床病理参数并不能解释该疾病的所有异质性及其不同的预后组。基因表达谱分析已带来了乳腺癌的新分类，并且新的检测方法正在作为预后和预测性检测进行开发和商业化。然而，在临床环境中使用这些检测方法存在许多问题。这项新技术的准确性常常被高估，其局限性应予以关注。尽管早期结果很有前景，但在将这些检测方法纳入常规临床实践之前，还需要进一步验证和精心设计的临床试验。
