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Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

作者信息

Michishita Eriko, McCord Ronald A, Boxer Lisa D, Barber Matthew F, Hong Tao, Gozani Or, Chua Katrin F

出版信息

Cell Cycle. 2009 Aug 15;8(16):2664-6. doi: 10.4161/cc.8.16.9367. Epub 2009 Aug 26.

Abstract
摘要

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SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
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Histone H3-K56 acetylation is important for genomic stability in mammals.
Cell Cycle. 2009 Jun 1;8(11):1747-53. doi: 10.4161/cc.8.11.8620. Epub 2009 Jun 3.
3
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells.
EMBO J. 2009 Jul 8;28(13):1878-89. doi: 10.1038/emboj.2009.119. Epub 2009 Apr 30.
4
CBP/p300-mediated acetylation of histone H3 on lysine 56.
Nature. 2009 May 7;459(7243):113-7. doi: 10.1038/nature07861. Epub 2009 Mar 8.
8
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Nature. 2008 Mar 27;452(7186):492-6. doi: 10.1038/nature06736. Epub 2008 Mar 12.
9
Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.
Mol Cell. 2007 Sep 21;27(6):890-900. doi: 10.1016/j.molcel.2007.07.021.
10
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication.
Science. 2007 Feb 2;315(5812):653-5. doi: 10.1126/science.1133234.

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