MRC Laboratory of Molecular Biology, Cambridge, U.K.
Biochem Soc Trans. 2024 Aug 28;52(4):1551-1564. doi: 10.1042/BST20230300.
The six-subunit shelterin complex binds to mammalian telomeres and protects them from triggering multiple DNA damage response pathways. The loss of this protective function by shelterin can have detrimental effects on cells. In this review, we first discuss structural studies of shelterin, detailing the contributions of each subunit and inter-subunit interactions in protecting chromosome ends. We then examine the influence of telomeric chromatin dynamics on the function of shelterin at telomeres. These studies provide valuable insights and underscore the challenges that future research must tackle to attain high-resolution structures of shelterin.
六亚基庇护复合物与哺乳动物端粒结合，保护它们免受多种 DNA 损伤反应途径的触发。庇护复合物丧失这种保护功能会对细胞产生有害影响。在这篇综述中，我们首先讨论庇护复合物的结构研究，详细介绍每个亚基的贡献以及亚基间相互作用在保护染色体末端方面的作用。然后，我们研究了端粒染色质动力学对庇护复合物在端粒上功能的影响。这些研究提供了有价值的见解，并强调了未来研究必须解决的挑战，以获得庇护复合物的高分辨率结构。
