Amyloid. 2009;16(3):174-7. doi: 10.1080/13506120903090874.
Two male patients aged 72 and 77 were found to have transthyretin (TTR) immunoreactive amyloid deposits in their gastrointestinal tracts when they underwent surgery for gastric and sigmoid colon cancer, respectively. They had no cardiac symptoms and there was no mutation in their TTR gene. Amyloid deposits were seen mainly on vascular walls in submucosal layers of the stomach and colon, while the muscularis mucosae, which is invariably affected in familial amyloid polyneuropathy (FAP), was completely free of amyloid deposition. The pattern of TTR-derived amyloid deposition in the gastrointestinal tract in SSA and in FAP are quite different.
两名 72 岁和 77 岁的男性患者分别因胃癌和乙状结肠癌接受手术时，发现其胃肠道中有转甲状腺素（TTR）免疫反应性淀粉样沉积物。他们没有心脏症状，TTR 基因也没有突变。淀粉样沉积物主要见于胃和结肠黏膜下层的血管壁，而在家族性淀粉样多发性神经病（FAP）中始终受累的黏膜肌层则完全没有淀粉样沉积物。SSA 和 FAP 中胃肠道 TTR 衍生淀粉样沉积物的沉积模式有很大的不同。
