Covey Thomas R, Thomson Bruce A, Schneider Bradley B
MDS Analytical Technologies, Sciex, Concord, Ontario, Canada L4K 4V8.
Mass Spectrom Rev. 2009 Nov-Dec;28(6):870-97. doi: 10.1002/mas.20246.
This review of atmospheric pressure ion sources discusses major developments that have occurred since 1991. Advances in the instrumentation and understanding of the key physical principles are the primary focus. Developments with electrospray and atmospheric pressure chemical ionization and variations encompassing adaptations for surface analysis, ambient air analysis, high throughput, and modification of the ionization mechanism are covered. An important and limiting consequence of atmospheric pressure chemical ionization, chemical noise, is discussed as is techniques being employed to ameliorate the problem. Ion transfer and transport from atmospheric pressure into deep vacuum is an area undergoing constant improvement and refinement so is given considerable consideration in this review.
本文对大气压离子源的综述讨论了自1991年以来发生的主要进展。仪器方面的进展以及对关键物理原理的理解是主要关注点。涵盖了电喷雾和大气压化学电离的发展以及包括表面分析、环境空气分析、高通量和电离机制改进等方面的变体。讨论了大气压化学电离的一个重要且具有局限性的结果——化学噪声，以及为改善该问题所采用的技术。从大气压到深真空的离子转移和传输是一个不断改进和完善的领域，因此在本综述中给予了相当多的关注。
