Lien Y H, Kam I, Shanley P F, Schröter G P
Department of Medicine, University of Colorado Health Sciences Center, Denver.
Am J Kidney Dis. 1991 Dec;18(6):711-5. doi: 10.1016/s0272-6386(12)80615-9.
Renal cell carcinoma (RCC) is a relatively uncommon cancer in renal transplant patients. From 1968 to 1987, 101 cases of RCC of native kidneys have been reported to the Cincinnati Transplant Tumor Registry. We describe here a case of metastatic RCC associated with acquired cystic kidney disease (ACKD) 15 years after successful renal transplantation. The patient presented with a subcutaneous nodule, which led to discovery of a large primary tumor in the left kidney. ACKD was present in the atrophic right kidney. The reported cases of ACKD-associated RCC in renal transplant recipients were reviewed. Most of these cases are middle-aged men with a long posttransplant course, good graft function, and usage of azathioprine and prednisone as immunosuppressive agents. ACKD can develop or persist and progress to RCC many years after successful renal transplantation. Transplant patients with flank pain, hematuria, or other suspicious symptoms should have imaging studies of their native kidneys.
肾细胞癌（RCC）在肾移植患者中是一种相对罕见的癌症。1968年至1987年期间，辛辛那提移植肿瘤登记处报告了101例原发性肾细胞癌病例。我们在此描述一例在成功肾移植15年后发生的与获得性囊性肾病（ACKD）相关的转移性肾细胞癌病例。患者出现皮下结节，进而发现左肾有一个大的原发性肿瘤。萎缩的右肾存在获得性囊性肾病。我们回顾了已报道的肾移植受者中与获得性囊性肾病相关的肾细胞癌病例。这些病例大多为中年男性，移植后病程长，移植肾功能良好，且使用硫唑嘌呤和泼尼松作为免疫抑制剂。获得性囊性肾病可在成功肾移植多年后发生、持续存在并进展为肾细胞癌。有侧腹痛、血尿或其他可疑症状的移植患者应进行其原生肾的影像学检查。
