氟哌啶醇和普萘洛尔对接受麦角酸二乙酰胺（LSD）治疗的小鼠行为及大脑生化变化的影响。
The influence of haloperidol and propranolol on behavior and biochemical changes in the brain of mice treated with LSD.
作者信息
Kocur J, Jurkowski A, Kedziora J
出版信息
Pol J Pharmacol Pharm. 1977 May-Jun;29(3):281-8.
The influence of haloperidol and propranolol on aggressiveness, motility exploration and general behavior, and the activity or level of adenylate cyclase, cyclic AMP, and protein kinase in the brain of mice treated with LSD was tested. Haloperidol evidently, and propranolol slightly less, inhibited the behavioral and biochemical changes induced by LSD. It is suggested that psychotomimetic effects of LSD depend on complex action of this compound on aminergic receptors in the central nervous system, and the antipsychotic effectiveness of haloperidol and propranolol is related to interaction of these drugs and LSD with the receptors for monoamines participating in the central neuromediation.
测试了氟哌啶醇和普萘洛尔对服用麦角酸二乙酰胺（LSD）的小鼠的攻击性、运动探索和一般行为，以及对其大脑中腺苷酸环化酶、环磷酸腺苷（cAMP）和蛋白激酶的活性或水平的影响。氟哌啶醇明显抑制了LSD诱导的行为和生化变化，普萘洛尔的抑制作用稍弱。提示LSD的拟精神病作用取决于该化合物对中枢神经系统中胺能受体的复杂作用，而氟哌啶醇和普萘洛尔的抗精神病效力与这些药物和LSD与参与中枢神经调节的单胺受体的相互作用有关。
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