School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.
J Interv Cardiol. 2009 Oct;22(5):466-78. doi: 10.1111/j.1540-8183.2009.00489.x. Epub 2009 Jul 13.
The aim of this article was to study the effect of dual drug-eluting stent (DES) on both restenosis and thrombosis in a porcine coronary artery model. This study reports on the use of two drugs coated on the stent to simultaneously minimize both restenosis and thrombosis. The DES was prepared by spray coating a bare metal stent with a biodegradable polymer loaded with sirolimus and triflusal, to treat against restenosis and thrombosis, respectively. The two-layered dual drug-coated stent was characterized in vitro for surface properties before and after expansion, as well as for possible delamination by cross-sectioning the stent in vitro. In vivo animal studies (in a pig model) were then performed for acute thrombosis, inflammation, and restenosis. The results show a significant reduction in restenosis with a stent coated with both drugs compared with the controls (a bare metal stent, a sirolimus-coated, and a pure polymer-coated stent). The reduction in restenosis with a sirolimus/triflusal-eluting stent is associated with an inhibition of inflammation and thrombus formation, suggesting that such dual DES have a role to play for the treatment of coronary artery diseases.
本文旨在研究双重药物洗脱支架（DES）对猪冠状动脉模型中再狭窄和血栓形成的影响。本研究报告了在支架上涂覆两种药物以同时最小化再狭窄和血栓形成的用途。DES 通过喷涂涂有载有西罗莫司和三氟柳的可生物降解聚合物的裸金属支架来制备，以分别针对再狭窄和血栓形成进行治疗。对双层双重药物涂层支架在扩张前后的表面特性以及通过体外切割支架进行分层的可能性进行了体外表征。然后在动物体内（猪模型）进行了急性血栓形成、炎症和再狭窄的研究。结果表明，与对照组（裸金属支架、西罗莫司涂层支架和纯聚合物涂层支架）相比，涂有两种药物的支架可显著减少再狭窄。西罗莫司/三氟柳洗脱支架减少再狭窄与抑制炎症和血栓形成有关，这表明这种双重 DES 在治疗冠状动脉疾病方面具有一定作用。
