Jagannathan Narasimhan, Sohn Lisa, Sawardekar Amod, Ambrosy Andrew, Hagerty Jennifer, Chin Anthony, Barsness Kathleen, Suresh Santhanam
Department of Pediatric Anesthesiology, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA.
Paediatr Anaesth. 2009 Sep;19(9):892-8. doi: 10.1111/j.1460-9592.2009.03092.x. Epub 2009 Jul 13.
Inguinal hernia repair, hydrocelectomy, and orchidopexy are commonly performed surgical procedures in children. Postoperative pain control is usually provided with a single-shot caudal block. Blockade of the ilioinguinal nerve may lead to additional analgesia. The aim of this double-blind, randomized controlled trial was to evaluate the efficacy of an adjuvant blockade of the ilioinguinal nerve using ultrasound (US) guidance at the end of the procedure with local anesthetic vs normal saline and to explore the potential for prolongation of analgesia with decreased need for postoperative pain medication.
Fifty children ages 1-6 years scheduled for unilateral inguinal hernia repair, hydrocelectomy, orchidopexy, or orchiectomy were prospectively randomized into one of two groups: Group S that received an US-guided ilioinguinal nerve block with 0.1 ml x kg(-1) of preservative-free normal saline and Group B that received an US-guided nerve block with 0.1 ml x kg(-1) of 0.25% bupivacaine with 1 : 200,000 epinephrine at the conclusion of the surgery. After induction of anesthesia but prior to surgical incision, all patients received caudal anesthesia with 0.7 ml x kg(-1) of 0.125% bupivacaine with 1 : 200,000 epinephrine. Patients were observed by a blinded observer for (i) pain scores using the Children and Infants Postoperative Pain Scale, (ii) need for rescue medication in the PACU, (iii) need for oral pain medications given by the parents at home.
Forty-eight patients, consisting of 46 males and two females, with a mean age of 3.98 (SD +/- 1.88) were enrolled in the study. Two patients were excluded from the study because of study protocol violation and/or alteration in surgical procedure. The average pain scores reported for the entire duration spent in the recovery room for the caudal and caudal/ilioinguinal block groups were 1.92 (SD +/- 1.59) and 1.18 (SD +/- 1.31), respectively. The average pain score difference was 0.72 (SD +/- 0.58) and was statistically significant (P < 0.05). In addition, when examined by procedure type, it was found that the difference in the average pain scores between the caudal and caudal/ilioinguinal block groups was statistically significant for the inguinal hernia repair patients (P < 0.05) but not for the other groin surgery patients (P = 0.13). For all groin surgery patients, six of the 23 patients in the caudal group and eight of the 25 patients in the caudal/ilioinguinal block group required pain rescue medications throughout their entire hospital stay or at home (P = 0.76). Overall, the caudal group received an average of 0.54 (SD +/- 1.14) pain rescue medication doses, while the caudal/ilioinguinal block group received an average of 0.77 (SD +/- 1.70) pain rescue medication doses; this was, however, not statistically significant (P = 0.58).
The addition of an US-guided ilioinguinal nerve block to a single-shot caudal block decreases the severity of pain experienced by pediatric groin surgery patients. The decrease in pain scores were particularly pronounced in inguinal hernia repair patients.
腹股沟疝修补术、鞘膜积液切除术和睾丸固定术是儿童常见的外科手术。术后疼痛控制通常采用单次骶管阻滞。髂腹股沟神经阻滞可能会带来额外的镇痛效果。本双盲随机对照试验的目的是评估在手术结束时使用超声(US)引导,用局部麻醉剂与生理盐水进行髂腹股沟神经辅助阻滞的疗效,并探讨延长镇痛时间以及减少术后止痛药需求的可能性。
50例年龄在1 - 6岁、计划进行单侧腹股沟疝修补术、鞘膜积液切除术、睾丸固定术或睾丸切除术的儿童被前瞻性随机分为两组:S组接受超声引导下0.1 ml/kg⁻¹的无防腐剂生理盐水髂腹股沟神经阻滞,B组在手术结束时接受超声引导下0.1 ml/kg⁻¹的含1:200,000肾上腺素的0.25%布比卡因神经阻滞。在麻醉诱导后但手术切口前,所有患者均接受0.7 ml/kg⁻¹的含1:200,000肾上腺素的0.125%布比卡因骶管麻醉。由一名盲法观察者观察患者:(i)使用儿童和婴儿术后疼痛量表评估疼痛评分;(ii)在麻醉后恢复室(PACU)对急救药物的需求;(iii)家长在家中给予口服止痛药的需求。
48例患者(46例男性,2例女性)纳入研究,平均年龄3.98岁(标准差±1.88)。2例患者因违反研究方案和/或手术程序改变而被排除在研究之外。骶管阻滞组和骶管/髂腹股沟阻滞组在恢复室的整个停留期间报告的平均疼痛评分分别为1.92(标准差±1.59)和1.18(标准差±1.31)。平均疼痛评分差异为0.72(标准差±0.58),具有统计学意义(P < 0.05)。此外,按手术类型检查时发现,骶管阻滞组和骶管/髂腹股沟阻滞组之间的平均疼痛评分差异在腹股沟疝修补术患者中具有统计学意义(P < 0.05),但在其他腹股沟手术患者中无统计学意义(P = 0.13)。对于所有腹股沟手术患者,骶管阻滞组23例患者中有6例,骶管/髂腹股沟阻滞组25例患者中有8例在整个住院期间或家中需要疼痛急救药物(P = 0.76)。总体而言,骶管阻滞组平均接受0.54(标准差±1.14)剂疼痛急救药物,而骶管/髂腹股沟阻滞组平均接受0.77(标准差±1.70)剂疼痛急救药物;然而,这无统计学意义(P = 0.58)。
在单次骶管阻滞基础上增加超声引导下的髂腹股沟神经阻滞可降低小儿腹股沟手术患者的疼痛严重程度。疼痛评分的降低在腹股沟疝修补术患者中尤为明显。