黑色素浓缩激素（MCH）受体介导野鲮黑色素细胞中黑素体聚集的证据。

Evidence for melanin concentrating hormone (MCH) receptors mediating melanosome aggregation in Labeo melanophores.

作者信息

Jain A K, Patil S

机构信息

Pigment Cell Biology Unit, School of Studies in Zoology, Jiwaji University, Gwalior.

出版信息

Indian J Physiol Pharmacol. 1990 Jul;34(3):187-90.

PMID:1962758

Abstract

Melanin concentrating hormone (MCH: 5 x 10(-12)-5 x 10(-8) M) induced a concentration related, rapid and reversible pigment aggregation in innervated melanophores of Labeo rohita. In inducing melanosome aggregation MCH was found to be 10(4) times more potent than norepinephrine. Experiments employing phentolamine and propranolol suggest that MCH acts through its own specific receptors on the melanophores unrelated to adrenoceptors. MCH was able to aggregate the melanosomes even in the absence of extracellular Ca2+.

摘要

黑色素浓集激素（MCH：5×10⁻¹² - 5×10⁻⁸ M）在露斯塔野鲮的受神经支配的黑素细胞中诱导了浓度相关的、快速且可逆的色素聚集。在诱导黑素小体聚集方面，发现MCH的效力比去甲肾上腺素强10⁴倍。使用酚妥拉明和普萘洛尔的实验表明，MCH通过黑素细胞上其自身的特异性受体起作用，与肾上腺素能受体无关。即使在没有细胞外Ca²⁺的情况下，MCH也能够使黑素小体聚集。