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[年轻健康人群中维生素D水平缺乏和不足的患病率]

[Prevalence of deficient and insufficient vitamin D levels in a young healthy population].

作者信息

Calatayud María, Jódar Esteban, Sánchez Raquel, Guadalix Sonsoles, Hawkins Federico

机构信息

Servicio de Endocrinología y Nutrición. Hospital Universitario 12 de Octubre. Madrid. España.

出版信息

Endocrinol Nutr. 2009 Apr;56(4):164-9. doi: 10.1016/S1575-0922(09)70980-5. Epub 2009 Jun 11.

Abstract

BACKGROUND AND OBJECTIVES

Recent studies have shown a high frequency of insufficient serum vitamin D levels in the general population, especially in the elderly and in individuals with osteoporosis. Data from the young adult population are scarce, but also reveal a high prevalence of vitamin D insufficiency and deficiency in this age group. The main reasons for this high prevalence seem to be poor dietary vitamin D intake and low sun exposure. The aim of the present study was to determine the prevalence of vitamin D insufficiency and deficiency in a young healthy population and its association with concentrations of calcium and parathyroid hormone and sun exposure.

METHODS

We performed an observational, descriptive study in 116 subjects (38 men and 78 women aged 26.56 +/- 3.32 years), during the late spring and early summer of 2007. Fasting blood samples were obtained and levels of 25-hydroxivitamin D, intact parathyroid hormone, calcium, albumin and creatinine were measured. A questionnaire designed to assess sun exposure and sunshine protection during the previous 12 months was administered.

RESULTS

The mean value of 25-hydroxivitamin D obtained was 24.58 +/- 6.98 ng/ml. The subjects were divided into three groups according to 25-hydroxivitamin D levels: deficient: < 20 ng/ml (27.58%); insufficient: 20-30 ng/ml (56.03%); and sufficient: > or = 30 ng/ml (16.37%). No statistically significant differences were found between the groups or the studied variables except for age in relation to vitamin D levels.

CONCLUSIONS

Our study shows a high prevalence of vitamin D insufficiency in a young healthy population with no clear relationship with sun exposure or sunscreen protection. The low intake of food rich in vitamin D and the lack of food fortification combined with scarce effective sun exposure could account for the low serum levels of vitamin D in this population.

摘要

背景与目的

近期研究表明,普通人群中血清维生素D水平不足的发生率很高,尤其是老年人和骨质疏松患者。关于年轻成年人的数据较少,但也显示该年龄组中维生素D不足和缺乏的患病率很高。这种高患病率的主要原因似乎是饮食中维生素D摄入量低和日照不足。本研究的目的是确定年轻健康人群中维生素D不足和缺乏的患病率及其与钙和甲状旁腺激素浓度以及日照的关系。

方法

2007年春末夏初,我们对116名受试者(38名男性和78名女性,年龄26.56±3.32岁)进行了一项观察性描述性研究。采集空腹血样,测量25-羟维生素D、完整甲状旁腺激素、钙、白蛋白和肌酐水平。发放一份旨在评估前12个月日照和防晒情况的问卷。

结果

测得的25-羟维生素D平均值为24.58±6.98 ng/ml。根据25-羟维生素D水平将受试者分为三组:缺乏组:<20 ng/ml(27.58%);不足组:20 - 30 ng/ml(56.03%);充足组:≥30 ng/ml(16.37%)。除了年龄与维生素D水平有关外,各分组之间以及所研究的变量之间未发现统计学上的显著差异。

结论

我们的研究表明,年轻健康人群中维生素D不足的患病率很高,且与日照或防晒无明显关系。富含维生素D的食物摄入不足、缺乏食品强化以及有效日照稀少可能是该人群血清维生素D水平低的原因。

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