Arimura Y, Nohmi K, Tanaka U, Nagasawa T
First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Nihon Jinzo Gakkai Shi. 1990 Oct;32(10):1087-93.
Anti-neutrophil cytoplasmic antibodies (ANCA) have been found in patients with systemic vasculitis and crescentic glomerulonephritis. Recently two types of ANCA were identified, one is anti-myeloperoxidase antibodies (Anti-MPO Ab) stained perinuclear pattern of alcohol-fixed neutrophils by immunofluorescence test, and the other is autoantibodies with no reactivity with myeloperoxidase stained diffuse cytoplasmic pattern (C-ANCA). We investigated 59 patients with various glomerulonephritis with or without crescent to detect anti-MPO Ab and C-ANCA by an enzyme-linked immunosorbent assay. The results were as follows: 1) Anti-MPO Ab were detected only in patients with various glomerulonephritis with crescent. 2) Titers of anti-MPO Ab were high related to percentage of crescent in some cases of glomerulonephritis. 3) Titers of anti-MPO Ab were elevated at stage of cellular and fibro-cellular crescent. 4) C-ANCA were detected only in patients with Wegener's granulomatosis. These data suggested that anti-MPO Ab may play important roles in crescent formation and may be a marker of crescent formation in various glomerulonephritis.
抗中性粒细胞胞浆抗体（ANCA）已在系统性血管炎和新月体性肾小球肾炎患者中被发现。最近，两种类型的ANCA被鉴定出来，一种是抗髓过氧化物酶抗体（Anti-MPO Ab），通过免疫荧光试验在酒精固定的中性粒细胞的核周模式下染色，另一种是与髓过氧化物酶无反应性的自身抗体，呈弥漫性胞浆模式染色（C-ANCA）。我们通过酶联免疫吸附测定法对59例有或无新月体的各种肾小球肾炎患者进行了研究，以检测抗MPO抗体和C-ANCA。结果如下：1）仅在有新月体的各种肾小球肾炎患者中检测到抗MPO抗体。2）在某些肾小球肾炎病例中，抗MPO抗体的滴度与新月体的百分比高度相关。3）在细胞性和纤维细胞性新月体阶段，抗MPO抗体的滴度升高。4）仅在韦格纳肉芽肿患者中检测到C-ANCA。这些数据表明，抗MPO抗体可能在新月体形成中起重要作用，并且可能是各种肾小球肾炎中新月体形成的一个标志物。
Zotero 插件