Yorioka N, Taniguchi Y, Amimoto D, Ogata S, Sakikubo E, Yamakido M, Naito T, Shimamoto F
Second Department of Internal Medicine, Hiroshima University, School of Medicine, Japan.
Clin Nephrol. 1999 Nov;52(5):293-6.
To investigate the potential prognostic factors for myeloperoxidase anti-neutrophil cytoplasmic antibody- (MPO-ANCA) associated glomerulonephritis.
The clinical and pathological findings were reviewed in 17 patients with this type of glomerulonephritis.
The relationship between the outcome and various clinical and pathological factors were assessed. The relationship between the blood MPO-ANCA level and cellular crescent formation was also investigated.
Patients who died had a significantly lower serum albumin and creatinine clearance than those who survived, but there were no differences of age, blood MPO-ANCA, urinary protein, and serum creatinine levels or cellular crescent formation between the two groups. There was a close relationship between blood MPO-ANCA levels and cellular crescent formation.
Hypoalbuminemia and renal dysfunction may be indicators of a poor prognosis in MPO-ANCA-associated glomerulonephritis. Patients with high blood levels of this antibody and increased cellular crescent formation appear to have active disease, but these factors are not statistically associated with a fatal outcome. Therefore, aggressive treatment may be indicated in patients with active disease initially.
探讨髓过氧化物酶抗中性粒细胞胞浆抗体（MPO-ANCA）相关肾小球肾炎的潜在预后因素。
回顾了17例此类肾小球肾炎患者的临床和病理表现。
评估结局与各种临床和病理因素之间的关系。还研究了血液MPO-ANCA水平与细胞性新月体形成之间的关系。
死亡患者的血清白蛋白和肌酐清除率显著低于存活患者，但两组在年龄、血液MPO-ANCA、尿蛋白、血清肌酐水平或细胞性新月体形成方面无差异。血液MPO-ANCA水平与细胞性新月体形成密切相关。
低白蛋白血症和肾功能不全可能是MPO-ANCA相关肾小球肾炎预后不良的指标。该抗体血液水平高且细胞性新月体形成增加的患者似乎患有活动性疾病，但这些因素与致命结局无统计学关联。因此，最初患有活动性疾病的患者可能需要积极治疗。
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