Unit of Molecular Haematology and Cancer Biology, University College London Institute of Child Health, London, United Kingdom.
Leuk Res. 2010 Jan;34(1):109-15. doi: 10.1016/j.leukres.2009.06.032. Epub 2009 Jul 22.
TEL-AML1 is an oncogenic fusion protein associated with childhood pre-B acute lymphoblastic leukaemia. From published microarray datasets we identified the Rho Guanine Nucleotide Exchange Factor (RhoGEF) Asef to be associated with TEL-AML1 leukaemia. However, the Asef gene is not a direct target of TEL-AML1 transcriptional control. Forced expression of Asef in vitro induced and maintained proliferation of haemaopoietic progenitor cells and co-operated with TEL-AML1 greatly to enhance proliferation and haemopoietic colony size. In haemopoietic transplantation reconstitution assays Asef and TEL-AML1 together failed to induce a leukaemic phenotype.
TEL-AML1 是一种与儿童前 B 急性淋巴细胞白血病相关的致癌融合蛋白。从已发表的微阵列数据集，我们确定 Rho 鸟苷酸交换因子（RhoGEF）Asef 与 TEL-AML1 白血病相关。然而，Asef 基因不是 TEL-AML1 转录控制的直接靶标。体外强制表达 Asef 诱导并维持造血祖细胞的增殖，并与 TEL-AML1 协同作用，极大地增强增殖和造血集落大小。在造血移植重建测定中，Asef 和 TEL-AML1 一起未能诱导白血病表型。
