雌激素对甲状旁腺激素的间接调节可能需要成纤维细胞生长因子23。
Indirect regulation of PTH by estrogens may require FGF23.
作者信息
Carrillo-López Natalia, Román-García Pablo, Rodríguez-Rebollar Ana, Fernández-Martín José Luis, Naves-Díaz Manuel, Cannata-Andía Jorge B
机构信息
Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación, Hospital Universitario Central de Asturias, REDinREN del ISCIII, Universidad de Oviedo, Oviedo, Asturias, Spain.
出版信息
J Am Soc Nephrol. 2009 Sep;20(9):2009-17. doi: 10.1681/ASN.2008121258. Epub 2009 Jul 23.
Abstract
The mechanisms by which estrogens modulate PTH are controversial, including whether or not estrogen receptors (ERs) are present in the parathyroid glands. To explore these mechanisms, we combined a rat model of CKD with ovariectomy and exogenous administration of estrogens. We found that estrogen treatment significantly decreased PTH mRNA and serum levels. We did not observe ERalpha or ERbeta mRNA or protein in the parathyroids, suggesting an indirect action of estrogens on PTH regulation. Estrogen treatment significantly decreased serum 1,25(OH)(2) vitamin D(3) and phosphorus levels. In addition, estrogens significantly increased fibroblast growth factor 23 (FGF23) mRNA and serum levels. In vitro, estrogens led to transcriptional and translational upregulation of FGF23 in osteoblast-like cells in a time- and concentration-dependent manner. These results suggest that estrogens regulate PTH indirectly, possibly through FGF23.
摘要
雌激素调节甲状旁腺激素（PTH）的机制存在争议，包括甲状旁腺中是否存在雌激素受体（ERs）。为了探究这些机制，我们将慢性肾脏病大鼠模型与卵巢切除术及外源性雌激素给药相结合。我们发现，雌激素治疗可显著降低PTH mRNA水平和血清PTH水平。我们在甲状旁腺中未观察到ERα或ERβ的mRNA或蛋白，提示雌激素对PTH调节存在间接作用。雌激素治疗可显著降低血清1,25(OH)₂维生素D₃和磷水平。此外，雌激素可显著提高成纤维细胞生长因子23（FGF23）的mRNA水平和血清水平。在体外，雌激素可导致成骨样细胞中FGF23的转录和翻译上调，且呈时间和浓度依赖性。这些结果表明，雌激素可能通过FGF23间接调节PTH。
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