[1,2-二甲基肼诱导的癌症在大肠淋巴集结中的主要定位]
[Primary localization of 1,2-dimethylhydrazine-induced cancer in lymphoid patches of the large intestine].
作者信息
Bandaletova T Iu
出版信息
Vopr Onkol. 1990;36(12):1456-61.
PMID:1962980
Abstract
Treatment with 1,2-dimethylhydrazine was performed according to body surface. The occurrence of tumors in the area of lymphoid patches in the ascending and descending parts of the colon was 6.7 and 1.5 times that outside the site, respectively. Signet-ring cell and mucinous carcinomas made up 92% of tumors arising in lymphoid patches. Treatment with the carcinogen was associated with decrease in the labelling index in lymphoid elements of interfollicular (T-dependent) zones of lymphoid patches from 6.6 +/- 1.8 to 4.1 +/- 1.6%.
摘要
按照体表面积给予1,2 - 二甲基肼进行治疗。结肠升段和降段淋巴滤泡区域的肿瘤发生率分别是该部位以外区域的6.7倍和1.5倍。印戒细胞癌和黏液癌占淋巴滤泡区域肿瘤的92%。给予致癌物治疗与淋巴滤泡间（T细胞依赖）区淋巴组织的标记指数从6.6±1.8%降至4.1±1.6%有关。
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