Aganova E A, Uranova N A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(10):53-7.
Electron microscopic morphometric study of synaptic contacts on dendritic spines and shafts was performed in layer II of the anterior cingulate cortex (area 24) of autopsy brain of paranoid schizophrenics (n-5), manic-depressive patients (MDP) (n-2) and controls (n-7). The areal synaptic density on dendritic spines increased significantly (p less than 0.001) in both groups of endogenous psychosis. The synaptic density on dendritic shafts decreased by 40% in schizophrenia and did not differ from controls in MDP. In schizophrenia, the percentage relations between different forms of synapses on dendritic spines (convex, concave and flat; symmetric and asymmetric; perforated and ++non-perforated++) differed from MDP and controls.
对偏执型精神分裂症患者（n = 5）、躁郁症患者（MDP）（n = 2）和对照组（n = 7）尸检大脑前扣带回皮质（24区）第二层的树突棘和树突干上的突触接触进行了电子显微镜形态计量学研究。在内源性精神病的两组中，树突棘上的局部突触密度均显著增加（p < 0.001）。精神分裂症患者树突干上的突触密度降低了40%，而躁郁症患者与对照组无差异。在精神分裂症中，树突棘上不同形式突触（凸形、凹形和平坦形；对称和不对称；穿孔和非穿孔）之间的百分比关系与躁郁症患者和对照组不同。
