College of Chemistry, Chemical Engineering and materials science, Soochow University, Suzhou 215123, People's Republic of China.
Luminescence. 2010 Jul-Aug;25(4):317-21. doi: 10.1002/bio.1154.
In this paper, a novel chemiluminescent (CL) method for the determination of benzhexol has been developed by combining the flow injection technique and its sensitizing effect on the weak CL reaction between sulfite and acidic cerium(IV). A mechanism for the CL reaction has been proposed on the basis of CL spectra. Under the optimized conditions, the proposed method allows the measurement of benzhexol hydrochloride over the range 0.1-10 microg/mL with a correlation coefficient of 0.9992 (n = 8), a detection limit of 0.02 microg/mL (3sigma), and a relative standard deviation for 2.0 microg/mL benzhexol (n = 11) of 1.65%. The utility of this method was demonstrated by determining benzhexol hydrochloride in tablets.
本文提出了一种将流动注射技术与亚硫酸盐和酸性铈(IV)之间的弱化学发光反应的敏化作用相结合，用于测定苯海索的新颖化学发光（CL）方法。根据 CL 光谱提出了 CL 反应的机制。在优化条件下，该方法允许测定盐酸苯海索在 0.1-10μg/mL 范围内，相关系数为 0.9992（n=8），检测限为 0.02μg/mL（3σ），相对标准偏差为 2.0μg/mL 苯海索（n=11）为 1.65%。该方法通过测定片剂中的盐酸苯海索得到了验证。
