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依匹斯汀：局部用眼科第二代抗组胺药，无明显全身副作用。

Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects.

作者信息

Pradhan Shilpi, Abhishek Kumar, Mah Francis

机构信息

University of Pittsburgh Medical Center, Eye and Ear Institute, PA 15213, USA.

出版信息

Expert Opin Drug Metab Toxicol. 2009 Sep;5(9):1135-40. doi: 10.1517/17425250903117284.

DOI:10.1517/17425250903117284
PMID:19630694
Abstract

BACKGROUND

Epinastine is a topical ophthalmic antihistamine and a mast cell stabilizer indicated for treatment of symptoms associated with allergic conjunctivitis.

OBJECTIVE

The objective of this review is to provide a comprehensive overview of the pharmacology, clinical efficacy, tolerability and safety of epinastine 0.05% ophthalmic solution.

METHODS

Medline literature review from 1950 to 2008.

CONCLUSIONS

Epinastine 0.05% ophthalmic solution was found to be a safe and effective medication for the relief of symptoms of allergic conjunctivitis. Epinastine demonstrates very low CNS and cardiac toxicity.

摘要

背景

依匹斯汀是一种局部用眼科抗组胺药和肥大细胞稳定剂，用于治疗与过敏性结膜炎相关的症状。

目的

本综述的目的是全面概述0.05%依匹斯汀滴眼液的药理学、临床疗效、耐受性和安全性。

方法

对1950年至2008年的医学文献进行综述。

结论

0.05%依匹斯汀滴眼液被发现是一种安全有效的缓解过敏性结膜炎症状的药物。依匹斯汀显示出非常低的中枢神经系统和心脏毒性。

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