Randolph G J
Department of Gene and Cell Medicine, and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
J Thromb Haemost. 2009 Jul;7 Suppl 1(Suppl 1):28-30. doi: 10.1111/j.1538-7836.2009.03423.x.
Monocytes are the primary inflammatory cell type that infiltrates early atherosclerotic plaques. Their recruitment into plaques drives disease progression. Disease interventions that target monocytes could act at several points: alteration in the phenotype of circulating monocyte subpopulations; reduced recruitment of monocytes into plaques; alterations in the survival of monocyte-derived cells in atherosclerosis; and promotion of migratory egress from plaques to bring about resolution of the plaque inflammatory response. All of these points of intervention will be briefly discussed in this article.
单核细胞是浸润早期动脉粥样硬化斑块的主要炎症细胞类型。它们募集到斑块中会推动疾病进展。针对单核细胞的疾病干预可在多个环节发挥作用：循环单核细胞亚群表型的改变；单核细胞向斑块募集的减少；动脉粥样硬化中单核细胞衍生细胞存活情况的改变；以及促进从斑块中迁移流出以促使斑块炎症反应消退。本文将简要讨论所有这些干预环节。
