起结合作用的Y蛋白：血小板中Src家族激酶活性的负调节因子
The Y's that bind: negative regulators of Src family kinase activity in platelets.
作者信息
Newman D K
机构信息
Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA.
出版信息
J Thromb Haemost. 2009 Jul;7 Suppl 1(0 1):195-9. doi: 10.1111/j.1538-7836.2009.03369.x.
Abstract
Members of the Src family of protein tyrosine kinases play important roles in platelet adhesion, activation, and aggregation. The purpose of this review is to summarize current knowledge regarding how Src family kinase activity is regulated in general, to describe what is known about mechanisms underlying SFK activation in platelets, and to discuss platelet proteins that contribute to SFK inactivation, particularly those that use phosphotyrosine-containing sequences to recruit phosphatases and kinases to sites of SFK activity.
摘要
蛋白酪氨酸激酶Src家族成员在血小板黏附、活化和聚集过程中发挥着重要作用。本综述的目的是总结目前关于Src家族激酶活性一般调控方式的知识，描述血小板中Src家族激酶（SFK）激活机制的已知情况，并讨论有助于SFK失活的血小板蛋白，特别是那些利用含磷酸酪氨酸序列将磷酸酶和激酶招募到SFK活性位点的蛋白。
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