Nieswandt B, Varga-Szabo D, Elvers M
Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.
J Thromb Haemost. 2009 Jul;7 Suppl 1:206-9. doi: 10.1111/j.1538-7836.2009.03370.x.
Heterodimeric receptors of the beta1 and beta3 integrin families mediate platelet adhesion and aggregation in hemostasis and thrombosis. In resting platelets, integrins are expressed in a low-affinity state but they shift to a high-affinity state and efficiently bind their ligands in response to cellular activation. This review summarizes recent advances in understanding the functional regulation and (patho-) physiological significance of individual platelet integrins with a special focus on studies in genetically modified mice. It is now recognized that beta1 and beta3 integrins have partially redundant roles in the adhesion process and that their activation is regulated by similar mechanisms, involving Ca2+-dependent and -independent signaling events and essential functions of talin-1 and kindlin-3 in the terminal activation step.
β1和β3整合素家族的异二聚体受体在止血和血栓形成过程中介导血小板黏附和聚集。在静息血小板中，整合素以低亲和力状态表达，但它们会转变为高亲和力状态，并在细胞激活时有效结合其配体。本综述总结了在理解单个血小板整合素的功能调节及其（病理）生理意义方面的最新进展，特别关注基因修饰小鼠的研究。现在人们认识到，β1和β3整合素在黏附过程中具有部分冗余作用，并且它们的激活受相似机制调节，涉及钙依赖性和非依赖性信号事件以及踝蛋白-1和纽带蛋白-3在终末激活步骤中的重要功能。
