Polc P, Ducić I
Pharma Research Department, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Brain Res. 1990 Oct 29;531(1-2):286-9. doi: 10.1016/0006-8993(90)90786-b.
Switching from a low (0.5 Hz) to a higher (5 Hz) frequency repetitive stimulation of hindlimb muscle nerve afferents reduced GABA-mediated dorsal root potentials and dorsal root reflexes in the lumbosacral cord of spinal cats. Benzodiazepine receptor antagonists flumazenil and Ro 15-3505 in a very low dose (0.03 mg/kg i.v.) reversed this effect suggesting a stimulation-coupled release of an endogenous benzodiazepine receptor ligand down-regulating GABAA-receptors in the spinal cord.
将后肢肌肉神经传入纤维的重复刺激频率从低（0.5赫兹）切换到高（5赫兹），可降低脊髓猫腰脊髓中GABA介导的背根电位和背根反射。苯二氮䓬受体拮抗剂氟马西尼和Ro 15 - 3505以极低剂量（静脉注射0.03毫克/千克）可逆转这种效应，这表明内源性苯二氮䓬受体配体通过刺激耦合释放，下调脊髓中的GABAA受体。
