Picazo Juan J, Betriu Carmen, Culebras Esther, Rodríguez-Avial Iciar, Gómez María, López Fátima
Servicio de Microbiología Clínica, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Diagn Microbiol Infect Dis. 2009 Aug;64(4):448-51. doi: 10.1016/j.diagmicrobio.2009.03.020.
We used the broth microdilution method to determine the MICs of daptomycin and 13 comparator agents against 319 methicillin-susceptible Staphylococcus aureus isolates, 201 methicillin-resistant S. aureus (MRSA) isolates, and 183 coagulase-negative staphylococci (CoNS). Isolates were consecutively collected from bloodstream infections in 39 Spanish medical centers during a 3-month period (March through May 2008). Among MRSA, 1 isolate with intermediate susceptibility to vancomycin and 6 isolates resistant to linezolid were found. Nonsusceptibility to teicoplanin was detected in 3.9% of CoNS. Daptomycin was highly active against the staphylococcal blood isolates tested-all were inhibited at the daptomycin susceptibility breakpoint of < or = 1 microg/mL. Daptomycin retained its activity against the isolates that were resistant to teicoplanin or linezolid, or that had reduced susceptibility to vancomycin. These data suggest that daptomycin could be useful for the treatment of bloodstream infections caused by staphylococci.
我们采用肉汤微量稀释法测定了达托霉素及13种对照药物对319株甲氧西林敏感金黄色葡萄球菌、201株耐甲氧西林金黄色葡萄球菌（MRSA）及183株凝固酶阴性葡萄球菌（CoNS）的最低抑菌浓度（MIC）。在3个月期间（2008年3月至5月），从西班牙39个医疗中心的血流感染患者中连续收集分离菌株。在MRSA中，发现1株对万古霉素中度敏感，6株对利奈唑胺耐药。在3.9%的CoNS中检测到对替考拉宁不敏感。达托霉素对所检测的葡萄球菌血流分离株具有高度活性——所有菌株在达托霉素敏感折点≤1μg/mL时均被抑制。达托霉素对耐替考拉宁或利奈唑胺、或对万古霉素敏感性降低的分离株仍保持活性。这些数据表明，达托霉素可用于治疗由葡萄球菌引起的血流感染。
