单纯疱疹病毒再激活及向心性扩散并发听神经瘤切除术
Reactivation and centripetal spread of herpes simplex virus complicating acoustic neuroma resection.
作者信息
Jalloh Ibrahim, Guilfoyle Mathew R, Lloyd Simon K W, Macfarlane Robert, Smith Chris
机构信息
Department of Neurosurgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
出版信息
Surg Neurol. 2009 Nov;72(5):502-4. doi: 10.1016/j.surneu.2008.11.002. Epub 2009 Jul 23.
BACKGROUND
Herpes simplex is a common human pathogen that has rare but severe manifestations including encephalitis.
CASE DESCRIPTION
A 44-year-old man underwent uneventful resection of an acoustic neuroma. Postoperatively, he developed swinging pyrexia, vomiting, and episodic confusion. Analysis of cerebrospinal fluid showed a lymphocytosis, and polymerase chain reaction revealed herpes simplex DNA. After treatment of herpes encephalitis with acyclovir, the patient made a good recovery.
CONCLUSION
Herpes encephalitis is a rare complication of neurosurgical procedures, and the most likely etiology is reactivation of latent infection from manipulation of cranial nerves.
背景
单纯疱疹是一种常见的人类病原体，有罕见但严重的表现，包括脑炎。
病例描述
一名44岁男性顺利接受了听神经瘤切除术。术后，他出现了波动性发热、呕吐和发作性意识模糊。脑脊液分析显示淋巴细胞增多，聚合酶链反应检测出单纯疱疹病毒DNA。用阿昔洛韦治疗疱疹性脑炎后，患者恢复良好。
结论
疱疹性脑炎是神经外科手术的一种罕见并发症，最可能的病因是因颅神经操作导致潜伏感染激活。
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