Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands.
J Reprod Immunol. 2009 Nov;82(2):148-57. doi: 10.1016/j.jri.2009.05.003. Epub 2009 Jul 23.
Human leukocyte antigen-C (HLA-C) is the only polymorphic classical histocompatibility antigen expressed by fetal trophoblasts at the fetal-maternal interface. Interactions between HLA-C and decidual natural killer (NK) cells may facilitate trophoblast invasion into maternal tissue. Thus far no evidence has been provided that decidual T cells specifically recognize and respond to fetal alloantigens at the fetal-maternal interface. In this study, we show that pregnancies containing a HLA-C mismatched child induce an increased percentage of CD4(+)CD25(dim) activated T cells in decidual tissue. In addition, HLA-C mismatched pregnancies exhibit a decidual lymphocyte response to fetal cells and contain functional CD4(+)CD25(bright) regulatory T cells in decidual tissue, whereas HLA-C matched pregnancies do not. This suggests that decidual T cells specifically recognize fetal HLA-C at the fetal-maternal interface but are prevented from inducing a destructive immune response in uncomplicated pregnancies.
人类白细胞抗原-C（HLA-C）是胎儿-母体界面上唯一表达的胎儿滋养层多态性经典组织相容性抗原。HLA-C 与蜕膜自然杀伤（NK）细胞之间的相互作用可能有助于滋养细胞侵入母体组织。到目前为止，尚无证据表明蜕膜 T 细胞专门在胎儿-母体界面识别和响应胎儿同种异体抗原。在这项研究中，我们表明，含有 HLA-C 错配儿童的妊娠会导致蜕膜组织中 CD4(+)CD25(dim)活化 T 细胞的百分比增加。此外，HLA-C 错配妊娠对胎儿细胞表现出蜕膜淋巴细胞反应，并在蜕膜组织中含有功能性 CD4(+)CD25(bright)调节性 T 细胞，而 HLA-C 匹配的妊娠则没有。这表明，在胎儿-母体界面，蜕膜 T 细胞特异性识别胎儿 HLA-C，但在无并发症的妊娠中，它们被阻止引发破坏性免疫反应。
