Takeda R, Momose Y, Haji A
Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Eur J Pharmacol. 1990 Sep 21;186(2-3):189-96. doi: 10.1016/0014-2999(90)90433-7.
Twitch contractions of the isolated guinea-pig vas deferens induced by sympathetic nerve stimulation were augmented by acetaldehyde (0.1-10 mM). With high concentrations (5-10 mM), acetaldehyde produced a biphasic response consisting of an initial brief depression and a subsequent potentiation of the contraction. The late effect was associated with repetitive contractions that were not prevented by tetrodotoxin. A low concentration of phentolamine (27 microM) increased and a high concentration (1.3 mM) suppressed the potentiating action of acetaldehyde. Acetaldehyde did not induce contractions in surgically sympathectomized vasa or vasa pretreated with reserpine. Acetaldehyde caused a dose-dependent increase in noradrenaline release into the bathing fluid. The study shows that acetaldehyde has a dual effect on sympathetic neuroeffector transmission, and that an increase in noradrenaline secretion appears to contribute to the late facilitatory effect in the isolated vas deferens.
交感神经刺激诱导的离体豚鼠输精管的抽搐性收缩，可被乙醛（0.1 - 10 mM）增强。高浓度（5 - 10 mM）时，乙醛产生双相反应，包括最初的短暂抑制和随后的收缩增强。后期效应与重复收缩有关，且这种重复收缩不受河豚毒素的抑制。低浓度的酚妥拉明（27 microM）增强而高浓度（1.3 mM）抑制乙醛的增强作用。乙醛在手术去交感神经的输精管或用利血平预处理的输精管中不诱导收缩。乙醛导致灌流液中去甲肾上腺素释放呈剂量依赖性增加。该研究表明，乙醛对交感神经效应器传递有双重作用，且去甲肾上腺素分泌增加似乎促成了离体输精管中的后期促进效应。
