Evidenced-based review of clinical studies on non-surgical endodontic treatment.

Non-surgical endodontic treatment represents a cornerstone of contemporary endodontic care. Reflecting the central importance of this therapy, there is a high number of studies that address issues related to this treatment. Unfortunately, many of these studies are preclinical "bench top" studies with largely undefined clinical implications. Given its high level of importance, we encourage others to conduct high-quality endodontic studies in this area. The following represents an analysis of recent clinical studies on nonsurgical endodontic treatment.