Department of Medicine, University of California, San Francisco, San Francisco, California 94143-1354, USA.
Heart Rhythm. 2009 Aug;6(8 Suppl):S1-7. doi: 10.1016/j.hrthm.2009.02.010. Epub 2009 Feb 12.
Atrial fibrillation (AF) is a heterogeneous disease that presents in a wide range of clinical scenarios. Correspondingly, a diverse array of large animal models has developed for the study of AF. Different atrial substrate exists in these models, and quantitative analysis of the AF that develops in each case reveals unique characteristics. This article reviews the defining properties of several prominent AF animal models, with a focus on how spatiotemporal organization can discriminate between AF substrates. It addresses how spatiotemporal assessments have been extended to human AF and discusses the insights gained from these new analyses.
心房颤动（AF）是一种异质性疾病，可在多种临床情况下出现。相应地，为了研究 AF，已经开发出了多种大型动物模型。这些模型中存在不同的心房基质，对每种情况下发生的 AF 的定量分析揭示了独特的特征。本文回顾了几种突出的 AF 动物模型的定义特性，重点关注时空组织如何区分 AF 基质。它探讨了时空评估如何扩展到人类 AF，并讨论了从这些新分析中获得的见解。
