妊娠11至14周时血清五聚体蛋白-3水平：与母体及胎盘特征的关联

Serum pentraxin-3 levels at 11 to 14 weeks' gestation: association with maternal and placental characteristics.

作者信息

Baschat Ahmet A, Kasdaglis Tania L, Aberdeen Graham W, Turan Ozhan M, Kopelman Jerome L, Atlas Robert, Jenkins Chuka, Blitzer Miriam, Harman Christopher R

机构信息

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.

出版信息

Am J Obstet Gynecol. 2009 Sep;201(3):298.e1-6. doi: 10.1016/j.ajog.2009.05.039. Epub 2009 Jul 24.

DOI:10.1016/j.ajog.2009.05.039

PMID:19631929

Abstract

OBJECTIVE

Pentraxin (PTX)-3 is an inflammatory molecule that may be increased in the first trimester in pregnancies with subsequent preeclampsia. We measured first-trimester serum PTX-3 and correlated levels with maternal/placental factors related to placental development.

STUDY DESIGN

Prospectively enrolled women had ultrasound, physical examination, and blood draw at 11-14 weeks. PTX-3 determined by enzyme-linked immunosorbent assay was related to maternal age, parity, race, body mass index (BMI), mean arterial blood pressure (MAP), smoking/caffeine, and uterine/umbilical artery Doppler pulsatility index (PI).

RESULTS

In 111 patients PTX-3 levels ranged from 0.2-13.8 ng/mL. Spearman correlation between PTX-3 and gestational age (rho = 0.096), maternal age (rho = -0.049), BMI (rho = -0.07), MAP (rho = -0.085), mean uterine artery PI (rho = 0.150), and umbilical artery PI (rho = -0.021) was nonsignificant (all P > .05). Similarly, PTX-3 distribution was unaffected by smoking/caffeine use, BMI >30, MAP >100 mm Hg, or uterine artery notching (P > .05 for all).

CONCLUSION

First-trimester PTX-3 is unrelated to maternal characteristics and placental Doppler.

摘要

目的

五聚体3（PTX-3）是一种炎症分子，在随后发生子痫前期的妊娠早期可能会升高。我们测量了妊娠早期血清PTX-3，并将其水平与胎盘发育相关的母体/胎盘因素进行关联。

研究设计

前瞻性纳入的女性在孕11至14周时进行超声检查、体格检查及采血。通过酶联免疫吸附测定法测定的PTX-3与母亲年龄、产次、种族、体重指数（BMI）、平均动脉血压（MAP）、吸烟/咖啡因摄入情况以及子宫/脐动脉多普勒搏动指数（PI）相关。

结果

111例患者的PTX-3水平在0.2至13.8 ng/mL之间。PTX-3与孕周（rho = 0.096）、母亲年龄（rho = -0.049）、BMI（rho = -0.07）、MAP（rho = -0.085）、子宫动脉平均PI（rho = 0.150）和脐动脉PI（rho = -0.021）之间的Spearman相关性无统计学意义（所有P >.05）。同样，PTX-3的分布不受吸烟/咖啡因使用、BMI>30、MAP>100 mmHg或子宫动脉切迹的影响（所有P>.05）。