细胞死亡：一种新的Par-4与肿瘤坏死因子相关凋亡诱导配体（TRAIL）。
Cell death: a new Par-4 the TRAIL.
作者信息
Hart Lori S, El-Deiry Wafik S
机构信息
Laboratory of Molecular Oncology and Cell Cycle Regulation, Department of Medicine (Hematology/Oncology), University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
出版信息
Cell. 2009 Jul 23;138(2):220-2. doi: 10.1016/j.cell.2009.07.007.
PMID:19632170
Abstract
The protein Par-4 acts in the cytoplasm to trigger cell death signaling via caspase activation and the mitochondrial release of cytochrome c. Burikhanov et al. (2009) now provide surprising evidence that Par-4 can also promote apoptosis from outside the cell, after its secretion in response to endoplasmic reticulum stress.
摘要
蛋白质Par-4在细胞质中发挥作用，通过激活半胱天冬酶和细胞色素c从线粒体释放来触发细胞死亡信号。Burikhanov等人（2009年）现在提供了惊人的证据，表明Par-4在因内质网应激而分泌后，也能从细胞外促进细胞凋亡。
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