特发性复发性嗜睡症综合征中下丘脑 - 垂体轴紊乱

Disturbed hypothalamic-pituitary axis in idiopathic recurring hypersomnia syndrome.

作者信息

Fernández J M, Lara I, Gila L, O'Neill of Tyrone A, Tovar J, Gimeno A

机构信息

Department of Neurology, Hospital Ramón y Cajal, Madrid, Spain.

出版信息

Acta Neurol Scand. 1990 Dec;82(6):361-3. doi: 10.1111/j.1600-0404.1990.tb03317.x.

DOI:10.1111/j.1600-0404.1990.tb03317.x

PMID:1963255

Abstract

Disturbed function of the hypothalamic-pituitary axis at adrenal and thyroid levels was found during an episode of hypersomnia in the idiopathic recurring hypersomnia syndrome. These endocrinological abnormalities, abolished ACTH and cortisol responses to insulin-induced hypoglycemia and absent TSH response to TRH, normalised thereafter in the symptom-free interval. These data support the hypothesis that Kleine-Levin syndrome is related to an intermittent hypothalamic dysfunction.

摘要

在特发性复发性嗜睡症综合征的一次嗜睡发作期间，发现下丘脑 - 垂体轴在肾上腺和甲状腺水平的功能紊乱。这些内分泌异常表现为促肾上腺皮质激素（ACTH）和皮质醇对胰岛素诱导的低血糖反应消失，促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）反应缺失，而在无症状期这些异常恢复正常。这些数据支持克莱因 - 莱文综合征与间歇性下丘脑功能障碍有关的假说。