作为硬脂酰辅酶A去饱和酶1抑制剂的噻唑类似物。
Thiazole analog as stearoyl-CoA desaturase 1 inhibitor.
作者信息
Li Chun Sing, Belair Liette, Guay Jocelyne, Murgasva Renata, Sturkenboom Wayne, Ramtohul Yeeman K, Zhang Lei, Huang Zheng
机构信息
Merck Frosst Centre for Therapeutic Research, 16711 TransCanada Hwy, Kirkland, Quebec, Canada.
出版信息
Bioorg Med Chem Lett. 2009 Sep 1;19(17):5214-7. doi: 10.1016/j.bmcl.2009.07.015. Epub 2009 Jul 9.
PMID:19632834
Abstract
SCD1 inhibition may represent a novel treatment for obesity, type-2 diabetes and related metabolic disorders. A prototype thiazole amide analog 13 (MF-152) was identified as an excellent tool in the study of SCD biology in animals.
摘要
硬脂酰辅酶A去饱和酶1（SCD1）抑制可能代表一种针对肥胖症、2型糖尿病及相关代谢紊乱的新型治疗方法。一种噻唑酰胺原型类似物13（MF - 152）被确定为研究动物体内SCD生物学的优良工具。
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