甲羟孕酮诱发的库欣综合征。

Medroxyprogesterone induced Cushing's syndrome.

作者信息

Learoyd D, McElduff A

机构信息

Department of Endocrinology, Royal North Shore Hospital, Sydney, NSW, Australia.

出版信息

Aust N Z J Med. 1990 Dec;20(6):824-5. doi: 10.1111/j.1445-5994.1990.tb00433.x.

DOI:10.1111/j.1445-5994.1990.tb00433.x

PMID:1963297

Abstract

A 74-year old female taking medroxyprogesterone acetate (MPA) presented with Cushing's syndrome together with low serum cortisol and plasma ACTH and an impaired response to synthetic ACTH (Synacthen, CIBA). When the medroxyprogesterone therapy was ceased the cushingoid features resolved and serum cortisol, ACTH and ACTH responsiveness all returned to normal. The MPA was acting as an exogenous glucocorticoid causing Cushing's syndrome.

摘要

一名74岁服用醋酸甲羟孕酮（MPA）的女性出现库欣综合征，同时伴有低血清皮质醇、血浆促肾上腺皮质激素（ACTH）以及对合成促肾上腺皮质激素（辛纳科特，汽巴公司生产）反应受损。停用甲羟孕酮治疗后，库欣样特征消失，血清皮质醇、促肾上腺皮质激素及促肾上腺皮质激素反应性均恢复正常。甲羟孕酮起到了外源性糖皮质激素的作用，导致了库欣综合征。