环二鸟苷酸变构抑制柑橘溃疡病菌的CRP样蛋白（Clp）。
Cyclic di-GMP allosterically inhibits the CRP-like protein (Clp) of Xanthomonas axonopodis pv. citri.
作者信息
Leduc Jason L, Roberts Gary P
机构信息
Department of Bacteriology, 1550 Linden Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.
出版信息
J Bacteriol. 2009 Nov;191(22):7121-2. doi: 10.1128/JB.00845-09. Epub 2009 Jul 24.
Abstract
The protein Clp from Xanthomonas axonopodis pv. citri regulates pathogenesis and is a member of the CRP (cyclic AMP receptor protein) superfamily. We show that unlike the DNA-binding activity of other members of this family, the DNA-binding activity of Clp is allosterically inhibited by its effector and that cyclic di-GMP serves as that effector at physiological concentrations.
摘要
来自柑橘溃疡病菌的Clp蛋白调控致病过程，并且是CRP（环腺苷酸受体蛋白）超家族的成员。我们发现，与该家族其他成员的DNA结合活性不同，Clp的DNA结合活性受到其效应物的变构抑制，并且环二鸟苷酸在生理浓度下充当该效应物。
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