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[低剂量辐射诱导细胞遗传学适应性反应的机制]

[Mechanism of cytogenetic adaptive response induced by low dose radiation].

作者信息

Cai L, Liu S

出版信息

Zhonghua Yi Xue Za Zhi. 1990 Nov;70(11):624-7, 44.

PMID:1963354
Abstract

Cytogenetic observation on human lymphocytes indicated that pre-exposure of 10, 50 and 75 mGy X-rays could induced the adaptive response. Experimental results with different temperature treatment showed that the adaptive response induced by low dose radiation could be enhanced by 41 degrees C and 43 degrees C, but inhibited by 4 degrees C in addition the treatment by 41 degrees C for one hour could also cause the adaptive response as did low dose radiation. Results showed that adaptive response induced by low dose radiation (10 or 50 mGy X-rays) could be eliminated by the protein synthesis inhibitor, implying that the adaptive response is related with the metabolism of cells, especially with the production of certain protective proteins.

摘要

对人类淋巴细胞的细胞遗传学观察表明,预先暴露于10、50和75毫戈瑞的X射线可诱导适应性反应。不同温度处理的实验结果表明,低剂量辐射诱导的适应性反应在41摄氏度和43摄氏度时会增强,但在4摄氏度时会受到抑制。此外,41摄氏度处理1小时也可像低剂量辐射一样引起适应性反应。结果表明,低剂量辐射(10或50毫戈瑞X射线)诱导的适应性反应可被蛋白质合成抑制剂消除,这意味着适应性反应与细胞代谢有关,尤其是与某些保护蛋白的产生有关。

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